All Publications
Nesbit KT, Hamdoun A. Embryo, larval, and juvenile staging of Lytechinus pictus from fertilization through sexual maturation [published online ahead of print, 2020 Jul 9]. Dev Dyn. 2020;10.1002/dvdy.223. doi:10.1002/dvdy.223. PMID:32644271 (Link)
Gordon WE, Espinoza JA, Leerberg DM, Yelon D, Hamdoun A. Xenobiotic transporter activity in zebrafish embryo ionocytes. Aquat Toxicology.2019 Apr 25;212:88-97. doi: 10.1016/j.aquatox.2019.04.013. [Epub ahead of print]. PMID: 31077970 (Link)
Schrankel CS, Gökirmak T, Lee CW, Chang G, Hamdoun A. Generation, expression and utilization of single-domain antibodies for in vivo protein localization and manipulation in sea urchin embryos. Methods Cell Biol.2019;151:353-376. doi: 10.1016/bs.mcb.2018.11.005. Epub 2019 Mar 9. PMID: 30948018 (Link)
Shipp LE, Hill RZ, Hamdoun A. A teaching laboratory on the activation of xenobiotic transporters at fertilization of sea urchins. Methods Cell Biol.2019;150:429-447. doi: 10.1016/bs.mcb.2018.11.013. Epub 2019 Feb 11. PMID: 30777187 (Link)
Campanale JP, Hamdoun A, Wessel GM, Su YH, Oulhen N. Methods to label, isolate, and image sea urchin small micromeres, the primordial germ cells (PGCs). Methods Cell Biol.2019;150:269-292. doi: 10.1016/bs.mcb.2018.11.007. Epub 2019 Jan 8. PMID: 30777180 (Link)
Nesbit KT, Fleming T, Batzel G, Pouv A, Rosenblatt HD, Pace DA, Hamdoun A, Lyons DC. The painted sea urchin, Lytechinus pictus, as a genetically-enabled developmental model. Methods Cell Biol.2019;150:105-123. doi: 10.1016/bs.mcb.2018.11.010. Epub 2019 Feb 10. PMID: 30777173 (Link)
Barron ME, Thies AB, Espinoza JA, Barott KL, Hamdoun A, Tresguerres M. A vesicular Na+/Ca2+ exchanger in coral calcifying cells. PLoS One. 2018 Oct 31;13(10):e0205367. doi: 10.1371/journal.pone.0205367. eCollection 2018. PMID: 30379874 (Link)
Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway. J Nat Prod.2018 Mar 23;81(3):506-514. doi: 10.1021/acs.jnatprod.7b00734. PMID: 29215273 (Link)
Hamdoun AH, Schrankel CS, Nesbit KT, Espinoza J. Sea Urchins as Lab Animals for Reproductive and Developmental Biology. 2018. In: Skinner M, Swanson P, editors. Encyclopedia of Reproduction, Second Edition. San Diego: Academic Press. (PDF)
Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. Geographic Differences in Persistent Organic Pollutant Levels of Yellowfin Tuna. Environ Health Perspect. 2017 Jun 26;125(6):067014. doi: 10.1289/EHP518. PMID: 28686554 (Link)
Nicklisch SCT, Bonito LT, Sandin S, Hamdoun A. Mercury levels of yellowfin tuna (Thunnus albacares) are associated with capture location. Environ Pollut.2017 May 31;229:87-93. doi: 10.1016/j.envpol.2017.05.070. PMID: 28577385 (Link)
Ramakrishnan L, Uhlinger K, Dale L, Hamdoun A, Patel S. ADP-ribosyl cyclases regulate early development of the sea urchin. Messenger (Los Angel). 2016 Jun 1;5(1-2):100-106. doi: 10.1166/msr.2016.1052. PMID: 28529830 (Link)
Gökirmak T, Campanale JP, Reitzel AM, Shipp LE, Moy GW, Hamdoun A. Functional diversification of sea urchin ABCC1 (MRP1) by alternative splicing. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C911-20. doi: 10.1152/ajpcell.00029.2016. Epub 2016 Apr 6. PMID: 27053522 (Link)
Nicklisch, SCT., Rees, SD., McGrath, AP., Gökirmak, T., Bonito, LT., Vermeer, LM., Cregger, C., Loewen, G., Sandin, S., Chang, G., and Hamdoun, A. Global marine pollutants inhibit Pglycoprotein: Environmental levels, inhibitory effects and co-crystal structure. Sci. Adv. 2016, e1600001. (Link)
Bonito LT, Hamdoun A, Sandin SA. Evaluation of the global impacts of mitigation on persistent, bioaccumulative and toxic pollutants in marine fish. PeerJ.2016 Jan 28;4:e1573. doi: 10.7717/peerj.1573. eCollection 2016. PMID: 26839747 (Link)
Shipp LE, Hill RZ, Moy GW, Gökırmak T, Hamdoun A. ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos. Development.2015 Oct 15;142(20):3537-48. doi: 10.1242/dev.126144. Epub 2015 Sep 22. PMID: 26395488 (Link)
Gökirmak, T., Shipp, L. E., Campanale, J. P., Nicklisch, S. C. T., Hamdoun, A. ABC transporters in technicolor: mapping of membrane proteins in embryos. Mol. Reprod. Dev. 2014. 812014, 778–793. (Link)
Campanale JP, Gökirmak T, Espinoza JA, Oulhen N, Wessel GM, Hamdoun A. Migration of sea urchin primordial germ cells. (2014) Dev Dyn. doi: 10.1002/dvdy.24133 (Link)
Cole, BJ, Hamdoun A and Epel, D. Cost effectiveness and environmental relevance of multi drug transporters in sea urchin embryos. (2013) J Exp Biol.2016: 3896-3905. (Link)
Gokirmak T, Campanale JP, Shipp LE, Moy GW, Tao H, Hamdoun A. (2012) Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters. J Biol Chem. 2012 Nov 2. PMID: 23124201. (Link)
Whalen K, Reitzel AM, Hamdoun A. Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli. Mol Biol Cell. 2012 Sep;23(18): 3663-72. (Link)
Shipp, L.E. and Hamdoun, A. (2012) ATP Binding Cassette transporter expression and localization in sea urchin development. Developmental dynamics. 241:1111-1124. (Link)
Campanale, J. P. and Hamdoun, A. (2012) Programmed reduction of ABC transporter activity in sea urchin germ line progenitors. Development. 139: 783-792. (Link)
Patel, S., Ramkrishnan, L., Rahman, T., Hamdoun, A., Marchant, J.S., Taylor, C.W., and Brailoiu, E. (2011). The endolysosomal system as an NAADP-sensitive acidic Ca (2+) store: role for the two-pore channels. Cell Calcium 50: 157-167. PMID: 21529939. (Link)
Bosnjak, I., Uhlinger, K.R., Heim, W., Smital, T., Franekic-Colic, J. Coale, K., Epel, D., Hamdoun, A. (2009) Multidrug Efflux Transporters Limit Accumulation of Inorganic, but Not Organic, Mercury in Sea Urchin Embryos. Environmental Science & Technology 43: 8374-8380. PMID: 19924972. (Link)
Hamdoun, A. (2009) Reduced intracellular accumulation of calcein by overexpression of fluorescent protein fusions of the multidrug transporter Sp-ABCB1a, in sea urchin (Strongylocentrotus purpuratus) embryos. MDIBL Bulletin. 48: 59-62. (PDF)
Epel, D., Stevenson, C.N., MacManus-Spencer, L.A., Luckenbach, T., Hamdoun A.and Smital, T. (2008) Efflux transporters: newly appreciated roles in protection against pollutants. Environmental Science and Technology. 42: 3914–3920. PMID: 18589945. (Link)
Hamdoun, A. and Epel, D. Embryo stability and vulnerability in an always changing world. (2007). PNAS 104, 1745-1750. (Link)
The Sea Urchin Genome Consortium. The Genome of the Sea Urchin, Strongylocentrotus purpuratus. Hamdoun, A., Defense Gene Group Leader. (2006) Science. 314: 941-952. PMID: 17095691. (Link)
Goldstone, J. V*, Hamdoun, A.* (*equal contributions), B.J. Cole, M.H. Ashby, M.Scally, M.E. Hahn, M. Dean, Epel, D. and J.J. Stegeman. (2006) The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Developmental Biology, 300(1), 366-384. (Link)
Roepke, T. A., Hamdoun, A. and G.N. Cherr. (2006) Increased drug transport activity is associated with the translocation of a MDR-related protein following induction of sea star oocyte maturation. Development, Growth and Differentiation, 48(9)559-573. PMID: 17118011. (Link)
Epel, D., Cole, B., Hamdoun A. and Vega, R.L. (2006). The sea urchin embryo as a model for studying efflux transporters: genomics, roles and energy cost of this protection system. Marine Environmental Research, 62, S1-S4. PMID: 16740304. (Link)
Hamdoun, A., Cherr, G.N., Roepke, T.A., and D. Epel (2004). Post-Translational Activation of MRP and P-gp Mediated Efflux Transport Activity at Fertilization in Sea Urchin Embryos (Strongylocentrotus purpuratus). Developmental Biology, 276, 452-462. PMID: 15581878. (Link)
Smital, T., Luckenbach, T., Sauerborn, R., Hamdoun, A., Vega, R. and Epel, (2004) Emerging contaminants – PPCPs, pesticides and microbial degradation products as inhibitors of the multixenobiotic defense in aquatic organisms. Mutation Research, 552, 101-117. PMID: 15288544. (Link)
Hamdoun, A., Cheney D. P. and Cherr, G.N. (2003). Phenotypic plasticity of HSPand HSP70 gene expression in the Pacific oyster (Crassostrea gigas): Implications for resting thermal limits and induction of thermal tolerance. Biological Bulletin, 205,160-169. (PDF)
Hamdoun, A., Griffin, F.J. and Cherr, G.N. (2002). Tolerance to biodegraded crude oil in marine invertebrate embryos and larvae is associated with expression of a multixenbiotic resistance transporter. Aquatic Toxicology, 61, 127-140. (PDF)