June 2016- Drug transporter evolution.
MRP transporters are an important group of transporters that translocate both signaling molecules and toxicants. Interestingly certain types of MRP transporters are only found in vertebrates but not invertebrates. Our recent study published in the American Journal of Physiology, Cell Physiology reveals that sea urchins can diversify the functions of MRP proteins by alternative splicing of transmembrane regions that bind the transporter’s substrates.
April 2016- “TICs” in our food.
Our recent study published in Science Advances reveals unanticipated effects of persistent organic pollutants on the mouse and human homologs of a critical cellular defense protein called P-glycoprotein (P-gp). The results indicate that these pollutants bind specifically to P-gp but inhibit the protein’s function rather than being transported by it. These Transporter Interfering Chemicals (TICs) could weaken this cellular defense pathway. The study was led by Hamdoun lab Postdoc. Dr. Sascha Nicklisch and covered by Time and the The Independent UK. (Photo by Lindsay Bonito)
September 2015: MRP5 in cyclic nucleotide signaling.
Recent research led by PhD Student Lauren Shipp reveals that the functions of of previously poorly understood drug transporter could include the transport of signaling molecules necessary for development. In this study Shipp and co-authors show that the sea urchin MRP5 is likely to play an important role in cyclic nucleotide signaling events necessary for completing gastrulation. You can read more about the results at this feature in Science Signaling.